Maynard Group Publications
2024
161) A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia
Daniele Vinciguerra, Rajalakshmi P S, Jane Yang, Katherine Snell, Panagiotis G. Georgiou, Théo Pesenti, Jeffrey Collins, Mikayla Tamboline, Shili Xu, R. Michael van Dam, Kathryn M. M. Messina, Andrea L. Hevener, Heather D. Maynard
160) Electronic Effects of Bidentate P,N-Ligands on the Elementary Steps of Au(I)/Au(III) Reactions Relevant to Cross-Coupling Chemistry
Joseph W. Treacy, Elaine Y. Chao, Grace E. Kunkel, Thomas Louis-Goff, James A. R. Tilden, Alexander M. Spokoyny, Heather D. Maynard, K. N. Houk
159) In Silico Screening of P,N-Ligands Facilitates Optimization of Au(III)-Mediated S-Arylation
Joseph W. Treacy, James A. R. Tilden, Elaine Y. Chao, Zihuan Fu, Alexander M. Spokoyny, K. N. Houk, Heather D. Maynard
158) Heterotelechelic Organometallic PEG Reagents Enable Modular Access to Complex Bioconjugates
Grace E. Kunkel, Joseph W. Treacy, Magdalena F. Polite, Hayden R. Montgomery, Evan A. Doud, K. N. Houk, Alexander M. Spokoyny, Heather D. Maynard
157) Polymer-mediated Protein/Peptide Therapeutic Stabilization: Current Progress and Future Directions
Rajalakshmi P Sivasankaran, Katherine Snell, Grace Kunkel, Panagiotis Georgiou, Ellie G. Puente, Heather D. Maynard
156) Organometallic Oxidative Addition Complexes for S-Arylation of Free Cysteines
Hayden R. Montgomery, Alexander M. Spokoyny, Heather D. Maynard
155) Comparison of Cyclic and Linear PEG Conjugates
Grace E. Kunkel, Qingyang Zhou, Joseph W. Treacy, Hayden R. Montgomery, Pedro Salas-Ambrosio, Austin D. Ready, Alexander M. Spokoyny, Kendall N. Houk, Heather D. Maynard
155) Ultrafast Au(III)-Mediated Arylation of Cysteine
Evan A. Doud, James A. R. Tilden, Joseph W. Treacy, Elaine Y. Chao, Hayden R. Montgomery, Grace E. Kunkel, Eileen J. Olivares, Nima Adhami, Tyler A. Kerr, Yu Chen, Arnold L. Rheingold, Joseph A. Loo, Christopher G. Frost, K. N. Houk, Heather D. Maynard, and Alexander M. Spokoyny
154) Evaluating polymerization kinetics using microrheology
Pedro Salas-Ambrosio, Caidric I. Gupit, Juan Manuel Urueña, Yimin Luo, Jeanne M. Hankett, Rohini Gupta, Megan T. Valentine, Heather D. Maynard, Matthew E. Helgeson
153) Uniform Trehalose Nanogels for Glucagon Stabilization
Ellie G. Puente, Rajalakshmi P. Sivasankaran, Daniele Vinciguerra, Jane Yang, Haillie-Ann C. Lower, Andrea Hevener, Heather D. Maynard
152) Controlling Rates and Reversibilities of Elimination Reactions of Hydroxybenzylammoniums by Tuning Dearomatization Energies
Zihuan Fu, Joseph Treacy, Brock Hosier, Kendall Houk, Heather Maynard
151) In situ analysis of osmolyte mechanisms of proteome thermal stabilization
Monika Pepelnjak, Britta Velten, Nicolas Näpflin, Tatjana von Rosen, Umberto Capasso Palmiero, Jeong Hoon Ko, Heather D. Maynard, Paolo Arosio, Eilika Weber-Ban, Natalie de Souza, Wolfgang Huber, Paola Picotti
150) Enzyme-polymer conjugates with photocleavable linkers for control over protein activity
Mikayla F. Tan, Brock M. Hosier, Neil L. Forsythe, Heather D. Maynard
149) Efficient end-group functionalization and diblock copolymer synthesis via Au(III) polymer reagents
Grace E. Kunkel, Joseph W. Treacy, Hayden R. Montgomery, Ellie G. Puente, Evan A. Doud, Alexander M. Spokoyny, Heather D. Maynard
2023
148) Growth Hormone Receptor Agonists and Antagonists: From Protein Expression and Purification to Long-Acting Formulations
Yue Wang, Minah Kim, Chantal Buckley, Heather D. Maynard, Ries J. Langley, and Jo K. Perry
147) Caffeine and Cationic Copolymers with Antimicrobial Properties
Pedro Salas-Ambrosio, Shelby Vexler, Rajalakshmi P S, Irene A. Chen, and Heather D. Maynard
2022
146) Noncovalent Enzyme Nanogels via a Photocleavable Linkage
Neil L. Forsythe, Mikayla F. Tan, Daniele Vinciguerra, Jacquelin Woodford, Adam Z. Stieg, and Heather D Maynard
145) Poly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety
Madeline B. Gelb, Kathryn M. M. Messina, Daniele Vinciguerra, Jeong Hoon Ko, Jeffrey Collins, Mikayla Tamboline, Shili Xu, F. Javier Ibarrondo, and Heather D. Maynard
144) Organometallic S-arylation Reagents for Rapid PEGylation of Biomolecules
Hayden R. Montgomery, Marco S. Messina, Evan A. Doud, Alexander M. Spokoyny, Heather D. Maynard
144) Synthesis and Application of Trehalose Materials
Daniele Vinciguerra, Madeline B. Gelb, Heather D. Maynard
143) Effects of Trehalose and Polyacrylate-Based Hydrogels on Tomato Growth Under Drought
Priera H Panescu, Marvin Browne, Kathleen K Chen, Lawren Sack, Heather D Maynard
142) Safety and Biodistribution Profile of Poly(Styrenyl Acetal Trehalose) And Its GCSF Conjugate
Jeong Hoon Ko, Neil L Forsythe, Madeline B Gelb, Kathryn M. M. Messina, Uland Y Lau, Arvind Bhattacharya, Tove Olafsen, Jason T Lee, Kathleen A Kelly, Heather D. Maynard
141) Self-Immolative Hydroxybenzylamine Linkers for Traceless Protein Modification
Douglas A. Rose, Joseph W. Treacy, Zhongyue J. Yang, Jeong Hoon Ko, Kendall N. Houk, and Heather D. Maynard
140) Diazido Macrocyclic Sulfates as a Platform for the Synthesis of Sequence-Defined Polymers for Antibody Drug Conjugates
Neil L. Forsythe, Mikayla F. Tan, and Heather D. Maynard
2021
139) Effect of Poly(trehalose methacrylate) Molecular Weight and Concentration on the Stability and Viscosity of Insulin
Madeline Gelb and Heather D. Maynard
138) Mesotrione Conjugation Strategies to Create Proherbicides with Reduced Soil Mobility
Priera H. Panescu, Douglas A. Rose, Kathleen K. Chen, Glareh Natalie Kashanchi, and Heather D. Maynard
137) Synthesis of Disulfide-Bridging Trehalose Polymers for Antibody and Fab Conjugation Using a Bis-Sulfone ATRP Initiator
Neil Forsythe, and Heather D. Maynard
Polym. Chem. 2021, 12, 1217-1223.
*Chosen as Paper of the Month
136) Enhanced Bioactivity of a Human GHR Antagonist Generated by Solid-Phase Site-Specific PEGylation
Yue Wang, Ries J. Langley, Kyle Tamshen, Julia Harms, Martin J. Middleditch, Heather D. Maynard, Stephen M. F. Jamieson, and Jo K. Perry
2020
135) Genetic Code Expansion Enables Site-Specific PEGylation of a Human Growth Hormone Receptor Antagonist through Click Chemistry
Kyle Tamshen, Yue Wang, Stephen Jamieson, Jo Perry, and Heather D. Maynard
134) Long-Acting Human Growth Hormone Receptor Antagonists Produced in E. coli and Conjugated with Polyethylene Glycol
Yue Wang, Ries J. Langley, Kyle Tamshen, Stephen M. Jamieson, Man Lu, Heather D. Maynard, and Jo K. Perry
133) Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin
Emma M. Pelegri-O’Day, Arvind Bhattacharya, Nik Theopold, Jeong Hoon Ko, and Heather D. Maynard
132) Modification of Proteins Using Olfein Metathesis
Marco S. Messina and Heather D. Maynard
131) Preparation of Biomolecule-Polymer Conjugates by Grafting-From using ATRP, RAFT, or ROMP
Marco S. Messina, Kathryn M. M. Messina, Arvind Bhattacharya, Hayden R. Montgomery, and Heather D. Maynard
2019
130) Electrically Mediated Membrane Pore Gating via Grafted Polymer Brushes
Chia Miang Khor, Xiaobo Zhu, Marco S. Messina, Sidney Poon, Xuan Yu Lew, Heather D. Maynard, and David Jassby
129) Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions
Elaine A. Qian, Yanxiao Han, Marco S. Messina, Heather D. Maynard, Petr Král, and Alexander M. Spokoyny
128) Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection
Jennifer A. Fulcher, Kyle Tamshen, Alexander L. Wollenberg, Valeria A. Kickhoefer, Jan Mrazek, Julie Elliot, F. Javier Ibarrondo, Peter A. Anton, Leonard H. Rome, Heather D. Maynard, Timothy Deming, and Otto O. Yang
127) Scalable Trehalose-Functionalized Hydrogel Synthesis for High Temperature Protection of Enzymes
Priera H. Panescu, Jeong Hoon Ko, and Heather D. Maynard
126) Carborane RAFT Agents as Tunable and Functional Molecular Probes for Polymer Materials
Marco S. Messina, Christian T. Graefe, Paul Chong, Omar M. Ebrahim, Ramya S. Pathuri, Nicholas A. Bernier, Harrison A. Mills, Arnold L. Rheingold, Renee R. Frontiera, Heather D. Maynard, and Alexander M. Spokoyny
125) Amphiphilic Fluorous Random Copolymer Self-Assembly for Encapsulation of a Fluorinated Agrochemical
Jeong Hoon Ko, Arvind Bhattacharya, Takaya Terashima, Mitsuo Sawamato, and Heather D. Maynard
2018
124) PEG Analogs Synthesized by Ring-Opening Metathesis Polymerization for Reversible Bioconjugation
Emma M. Pelegri-O’Day, Nicholas M. Matsumoto, Kyle Tamshen, Eric D. Raftery, Uland Y. Lau, and Heather D. Maynard
123) A Guide to Maximizing the Therapeutic Potential of Protein-Polymer Conjugates by Rational Design
Jeong Hoon Ko and Heather D. Maynard
ChemSocRev, 2018, 47, 8998-9014
*Chosen for cover of that issue
122) Polymers at the Interface with Biology
Timothy J. Deming, Harm-Anton Klock, Steven P. Armes, Matthew L. Becker, Julie A. Champion, Eugene X. Y. Chen, Sarah C. Heilshorn, Jan C. M. van Hest, Darrell J. Irvine, Jeremiah A. Johnson, Laura L. Kiessling, Heather D. Maynard, Monica Olvera de la Cruz, Millicent O. Sullivan, Matthew V. Tirrell, Kristi S. Anseth, Sebastien Lecommandoux, Simona Perce, Zhiyuan Zhong, and Ann-Christine Albertsson
121) Tuning Molecular Interactions for Highly Reproducible and Efficient Formamidinium Perovskite Solar Cells via Adduct Approach
Jin-Wook Lee, Zhenghong Dai, Changsoo Lee, Hyuck M. Lee, Tae-Hee Han, Nicholas De Marco, Oliver Lin, Christopher S. Choi, Bruce Dunn, Jaekyung Koh, Dino Di Carlo, Jeong H. Ko, Heather D. Maynard, and Yang Yang
120) Organometallic Au(III) Reagents for Cysteine Arylation
Marco S. Messina, Julia M. Stauber, Mary A. Waddington, Arnold L. Rheingold, Heather D. Maynard, and Alexander M. Spokoyny
119) Site-Specific Insulin-Trehalose Glycopolymer Conjugate by Grafting from Strategy Improves Bioactivity
Kathryn M. Mansfield and Heather D. Maynard
ACS Macro Lett, 2018, 7, 324-329
*Chosen for cover of that issue
118) Glucose-Responsive Trehalose Hydrogels for Insulin Stabilization and Delivery
Juneyoung Lee, Jeong H. Ko, Kathryn Mansfield, Peter C. Nauka, Erhan Bat, and Heather D. Maynard
117) Stabilization of Glucagon by Trehalose Glycopolymer Nanogels
Natalie Boehnke, Jacquelin K. Kammeyer, Robert Damoiseaux, and Heather D. Maynard
116) Synthesis and Biological Evaluation of a Degradable Trehalose Gylcopolymer Prepared by RAFT Polymerization
Uland Y. Lau, Emma M. Pelegri-O’Day, and Heather D. Maynard
2017
115) Ko, J. H.; Terashima, T.; Sawamoto, M.; Maynard, H. D. "Fluorous Comonomer Modulates the Reactivity of Cyclic Ketene Acetal and Degradation of Vinyl Polymers,” Macromolecules, 2017, 50, 9222-9232.
114) Paluck, S. J.; Maynard, H. D. "Structure Activity Relationship of Heparin Mimicking Polymer p(SS-co-PEGMA): Effect of Sulfonation and Polymer Size on FGF2 Receptor Binding," Polym. Chem. 2017, 8, 4548-4556.
113) Boehnke, N.; Maynard, H. D. "Design of Modular Dual-Enzyme Responsive Peptides," Peptide Science, 2017, 108, 1-6.
*Chosen for cover of that issue
112) Messina, M. S.; Ko, J. H.; Yang, Z.; Strousse, J. M.; Houk, K. N.; Maynard, H. D. "Effect of Trehalose Polymer Regioisomers on Protein Stabilization," Polym. Chem. 2017, 4781-4788.
*Chosen for cover of that issue
111) Brown, C. L.; Barbee, M. H.; Ko, J. H.; Maynard, H. D.; Craig, S. L. "Writing Without Ink: A Mechanically and Photochemically Responsive PDMS Polymer for Science Outreach," J. Chem. Ed. 2017, 94, 1752-1755.
110) Pelegri-O'Day, E. M.; Paluck, S. J.; Maynard, H. D. “Substituted Polyesters by Thiol–Ene Modification: Rapid Diversification or Therapeutic Protein Stabilization,” J. Am. Chem. Soc. 2017, 139, 1145-1154.
109) Medina, J. M.; Ko, J. H.; Maynard, H. D.; Garg, N. K. “Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry,” Macromolecules, 2017, 50, 580-586.
108) Liu, Y.; Lee, J. ; Mansfield, K. M.; Ho, J. K.; Sallam, S.; Wesdemiotis, C.; Maynard, H. D. “Trehalose Glycopolymer Enhances Both Solution Stability and Pharmacokinetics of a Therapeutic Protein,” Bioconjugate Chem. 2017, 28, 836-845.
*Highlighted in C&E News
107) Qian, E. A.; Wixtrom, A. I.; Axtell, J. C.; Saebi, A.; Wang, J. Y.; Jung, D.; Moully, E. H.; Mosallaei, D.; Chow, S.; Messina, M. S.; Rehak, P.; Han, Y.; Royappa, A. T.; Rheingold, A. L.; Maynard, H. D.; Král, P.; Spokoyny, A. M. “Atomically Precise Organomimetic Cluster Nanomolecules (OCNs) Assembled via Perfluoroaryl-Thiol SNAr Chemistry” Nature Chem. 2017, 9, 333-340.
*Highlighted by UCLA Chemistry and Biochemistry
2016
106) Paluck, S. J.; Nguyen, T. H.; Lee, J. P.; Maynard, H. D. “A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2),” Biomacromolecules, 2016, 17, 3386-3395.
*Chosen for cover of that issue
105) Koda, Y.; Terashima, T.; Maynard, H. D.; Sawamoto, M. “Protein Storage with Perfluorinated PEG Compartments in a Hydrofluorocarbon Solvent,” Polym. Chem. 2016, 7, 6694-6698.
*Chosen for cover of that issue
104) Paluck, S. J.; Nguyen, T. H.; Maynard, H. D. “Heparin-Mimicking Polymers: Synthesis and Biological Applications,” Biomacromolecules, 2016, 17, 3417-3440.
103) Pelegri-O’Day, E. M.; Maynard, H. D. “Controlled Radical Polymerization as an Enabling Approach for the Next Generation of Protein-Polymer Conjugates,” Acc. Chem. Res. 2016, 49, 1777-1785.
102) Vanparijs, N.; Nuhn, L.; Paluck, S. J.; Maynard, H. D.; De Geest, B. G. “Core and Shell Reactive Nanogels for Protein Conjugation via a Combination of RAFT Polymerization and Vinyl Sulfone Post-Modification,” Nanomedicine, 2016, 11, 2631-2645.
101) Messina, M. S.; Axtell, J. C.; Wang, Y.; Chong, P.; Wixtrom, A. I.; Kirlikovali, K. O.; Upton, B. M.; Hunter, B. H.; Shafaat, O. S.; Khan, S. I.; Winkler, J. R.; Gray, H. B.; Alexandrova, A. N.; Maynard, H. D.; Spokoyny, A. M. "Visible Light-Induced Olefin Activation using 3D Aromatic Boron-Rich Cluster Photooxidants," J. Am. Chem. Soc. 2016, 138, 6952-6955.
*Highlighted by P. Szuromi in Science
*Highlighted by UCLA Chemistry and Biochemistry
*Highlighted in C&EN Talented 12 article
100) Mancini, R. J.; Paluck, S. J.; Bat, E.; Maynard, H. D. "Encapsulated Hydrogels by E-Beam Lithography and Their Use in Enzyme Cascade Reactions," Langmuir, 2016, 32, 4043-4051.
99) Nauka, P. N.; Lee, J.; Maynard, H. D. "Enhancing Conjugation Yield of Brush Polymer Protein-Polymer Conjugates by Increasing Linker Length at the Polymer End Group," Polym. Chem. 2016, 7, 2352-2357.
98) Lorenzo, M. M.; Decker, C. G.; Kahveci, M. U.; Paluck, S. J.; Maynard, H. D. "Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation," Macromolecules, 2016, 49, 30-37.
97) Lau, U. Y.; Saxer, S. S.; Lee, J.; Bat, E.; Maynard, H. D. "Direct Write Protein Patterns for Multiplexed Cytokine Detection from Live Cells Using Electron Beam Lithography," ACS Nano, 2016, 10, 723-729.
96) Shen, L.; Decker, C. G.; Maynard, H. D.; Levine, A. J., “Mean Time to Capture for Tethered Ligands and Its Effect on the Chemical Equilibrium of Bound Ligand Pairs,” Data in Brief, 2016, 8, 506-515.
95) Decker, C. G.; Wang, Y.; Paluck, S. J.; Shen, L.; Loo, J. A.; Levine, A. J.; Miller, L. S.; Maynard, H. D. "Fibroblast Growth Factor 2 Dimer with Superagonist In Vitro Activity Improves Granulation Tissue Formation During Wound Healing," Biomaterials, 2016, 81, 157-168.
2015
94) Maynard, H. D. "Protein Modification in a Trice," Nature, 2015, 526, 646-647.
93) Nguyen, T. H.; Paluck, S. J.; McGahran, A. J.; Maynard, H. D. "Poly(vinyl sulfonate) Facilitates bFGF-Induced Cell Proliferation," Biomacromolecules, 2015, 16, 2684-2692.
92) Lin, E. W.; Maynard, H. D. "Grafting from Small Interfering Ribonucleic Acid (siRNA) as an Alternative Synthesis Route to siRNA-Polymer Conjugates," Macromolecules, 2015, 48, 5640-5647.
91) Boehnke, N.; Cam, C.; Bat, E.; Segura, T.; Maynard, H. D. "Imine Hydrogels with Tunable Degradability for Tissue Engineering," Biomacromolecules, 2015, 16, 2101-2108.
90) Lee, J.; Ko, J. H.; Lin, E.-W.; Wallace, P.; Ruch, F.; Maynard, H. D. "Trehalose Hydrogels for Stabilization of Enzymes to Heat," Polym. Chem. 2015, 6, 3443-3448.
89) Bat, E.; Lee, J.; Lau, U. Y.; Maynard, H. D. "Trehalose Glycopolymer Resists Allow Direct Writing of Protein Patterns by Electron-Beam Lithography," Nat. Commun., 2015, 6, 6654-6661.
88) Matsumoto, N.M.; Buchman, G. W.; Rome, L. H.; Maynard, H. D. "Dual pH- and Temperature-Responsive Protein Nanoparticles," Eur. Polym. Journal, 2015, 69, 532-539.
87) Decker, C. G.; Maynard, H. D. "Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization," Eur. Polym. Journal, 2015, 65, 305-312.
86) Koda, Y.; Terashima, T.; Sawamoto, M.; Maynard, H. D., "Amphiphilic/Fluorous Random Copolymers as a New Class of Biocompatible Polymeric Materials for Protein Conjugation," Polym. Chem. 2015, 6, 240-247.
*Chosen for cover of that issue
*Selected as paper of the week
2014
85) Lin, E.-W.; Boehnke, N.; Maynard, H. D. "Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-Transferase" Bioconjugate Chem. 2014, 25, 1902-1909.*
*ACS Editor's choice
84) Pelegri-O'Day, E. M.; Lin, E.-W.; Maynard, H. D. "Therapeutic Protein-Polymer Conjugates: Advancing Beyond PEGylation," J. Am. Chem. Soc. 2014, 136, 14323-14332.
83) Bat, E.; Lin, E.-W.; Saxer, S.; Maynard, H. D. "Morphing Hydrogel Patterns by Thermo-Reversible Fluorescence Switching," Macro. Rapid Commun. 2014, 35, 1260-1265.
82) Upton, B. M.; Gipson, R. M.; Duhovic, S.; Lydon, B. R.; Matsumoto, N. M.; Maynard, H. D.; Diaconescu, P. "Synthesis of Ferrocene- Functionalized Monomers for Biodegradable Polymer Formation," Inorganic Chem. Frontiers, 2014, 1, 271-277.
81) De la Rica, R.; Bat, E.; Herpoldt, K. L.; Xie, H.-n.; Bertazzo, S.; Maynard, H. D.; Stevens, M. M. "Nanoparticle Growth via Concentration Gradients Generated by Enzyme Nanopatterns," Adv. Funct. Mater. 2014, 24, 3692-3698.
*Chosen for cover of that issue
2013
80) Tolstyka, Z. P.; Richardson, W.; Bat, E.; Stevens, C. J.; Parra, D. P.; Dozier, J. K.; Distefano, M. D.; Dunn, B.; Maynard, H. D. "Chemoselective Immobilization of Proteins by Microcontact Printing and Bioorthogonal Click Reactions," ChemBioChem, 2013, 14, 2464-2471.
79) Lee, J.; Lin, E.-W.; Lau, U. Y.; Hedrick, J. L.; Bat, E.; Maynard, H. D. "Trehalose Glycopolymers as Excipients for Protein Stabilization," Biomacromolecules, 2013, 14, 2561-2569.
78) Maynard, H. D. "Protein in a Pill," Nature Chem. 2013, 5, 557-558.
77) Nauka, P; Maynard, H.D. "Creative and Novel Applications of Poly(Ethylene Glycol)," The UCLA Undergraduate Science Journal. 2013, 76-81.
76) Alconcel, S. N. S.; Kim, S. H.; Tao, L.; Maynard, H. D. "Synthesis of Biotinylated Aldehyde Polymers for Biomolecule Conjugation," Macro. Rapid Commun. 2013, 34, 983-989.
*Highlighted by MaterialsViews
75) Griffin, D. R.; Schlosser, J. L.; Lam, S. F.; Nguyen, T. H.; Maynard, H. D.; Kasko, A. M. "Synthesis of Photodegradable Macromers for Conjugation and Release of Bioactive Molecules," Biomacromolecules, 2013, 14, 1199-1207.
74) Matsumoto, N. M.; Gonzalez-Toro, D. C.; Chacko, R. T.; Maynard, H. D.; Thayumanavan, S. "Synthesis of Nanogel-Protein Conjugates," Polym. Chem. 2013, 4, 2464-2469.
73) Matsumoto, N. M.; Prabhakaran, P.; Rome, L. H.; Maynard, H. D. "Smart Vaults: Thermally-Responsive Protein Nanocapsules," ACS Nano, 2013, 7, 867-874.
72) Nguyen, T. H.; Kim, S.-H.; Decker, C. G.; Wong, D. Y.; Loo, J. A.; Maynard, H. D. "A Heparin-Mimicking Polymer Conjugate Stabilizes Basic Fibroblast Growth Factor," Nat. Chem. 2013, 5, 221-227.
*Highlighted by C&E News, FierceBiotechResearch, Metro US , ScienceDaily, Medical Xpress, Examiner, News-Medical, Domain-b, UCLA Physical Sciences, UCLA Newsroom, UC Newsroom, UC Health, UCLA Department of Chemistry and Biochemistry, RedOrbit, Vyagers, ScienceCodex, Scicasts, Isaude, Science Newsline, EurekAlert!, WoundCareJobs, Physics News, International Hospital, Press-News.org, Grays Medicine
71) Liu, J.; Li, R. C.; Sand, G. J.; Bulmus, V.; Davis, T. P.; Maynard, H. D. "Keto-Functionalized Polymer Scaffolds as Versatile Precursors to Polymer Side Chain Conjugates," Macromolecules, 2013, 46, 8-14.
2012
70) Vazquez-Dorbatt, V.; Lee, J.; Lin, E.-W.; Maynard, H. D. "Synthesis of Glycopolymers by Controlled Radical Polymerization Techniques and Their Applications," ChemBioChem, 2012, 13, 2478-2487.
69) Grover, G. N.; Lam, J.; Nguyen, T. H.; Segura, T.; Maynard, H. D. "Biocompatible Hydrogels by Oxime Click Chemistry," Biomacromolecules, 2012, 13, 3013-3017.
*Highlighted by Global Medical Discovery
68) Kolodziej, C. M.; Maynard, H. D. "Shape-Shifting Micro and Nano-Patterns Controlled by Temperature," J. Am. Chem. Soc. 2012, 134, 12386-12389.
67) Grover, G. N.; Lee, J.; Matsumoto, N. M.; Maynard, H. D. "Aminooxy and Pyridyl Disulfide Telechelic Poly(poly(ethylene glycol) acrylate) by RAFT Polymerization," Macromolecules, 2012, 45, 4958-4965.
66) Mancini, R. J.; Lee, J.; Maynard, H. D. "Trehalose Glycopolymers for Stabilization of Protein Conjugates to Environmental Stressors," J. Am. Chem. Soc. 2012, 134, 8474-8479.
*Highlighted by UCLA Newsroom
*Highlighted by C&E News
65) Kolodziej, C. M.; Maynard, H. D. "Electron-Beam Lithography for Patterning Biomolecules at the Micron and Nanometer Scale," Chem. Mater. 2012, 24, 774-780.
64) Kolodziej, C. M.; Kim, S. H.; Broyer, R. M.; Saxer, S. S.; Decker, C. G.; Maynard, H. D. "Combination of Integrin-Binding Peptide and Growth Factor Promotes Cell Adhesion on Electron-Beam Fabricated Patterns," J. Am. Chem. Soc. 2012, 134, 247-255.
63) Tolstyka, Z.; Maynard, H. D., "Protein-Polymer Conjugates," in Comprehensive Polymer Science, Edited by K. Matyjaszewski and M. Moller, Elsevier, 2012, vol 9, pp 317-337.
2011
62) Kim, S. H.; Nguyen, T. H.; Maynard, H. D. "Polymeric Drug Conjugates by Controlled Radical Polymerization," in Comprehensive Biomaterials, Edited by P. Ducheyne, K. Healy, D. Hutmacher, J. Kirkpatrick, Elsevier, 2011, vol 4, part 423, pp 377-388.
61) Broyer, R. M.; Schopf, E.; Kolodziej, C. M.; Chen, Y.; Maynard, H. D. "Dual Click Reactions to Micropattern Proteins," Soft Matter, 2011, 7, 9972-9977.
60) Alconcel, S. N. S.; Baas, A. S.; Maynard, H. D. "FDA-Approved Poly(Ethylene Glycol)-Protein Conjugate Drugs," Polym. Chem. 2011, 2, 1442-1448.
59) Gunasekaran, K.; Nguyen, T. H.; Maynard, H. D.; Davis, T. P.; Bulmus, V. "Conjugation of siRNA with Comb-Type PEG Enhances Serum Stability and Gene Silencing Efficiency," Macromol. Rapid Commun. 2011, 32, 654-659.
58) Broyer, R. M.; Grover, G. N.; Maynard, H. D. "Emerging Synthetic Approaches for Protein-Polymer Conjugations," Chem. Commun. 2011, 47, 2212-2226.
57) Christman, K. L.; Broyer, R. M.; Schopf, E.; Kolodziej, C. M.; Chen, Y.; Maynard, H. D. "Protein Nanopatterns by Oxime Bond Formation," Langmuir, 2011, 27, 1415-1418.
56) Kolodziej, C. M.; Chang, C. W.; Maynard, H. D. "Glutathione S-Transferase as a General and Reversible Tag for Surface Immobilization of Proteins," J. Mater. Chem. 2011, 21, 1457-1461.*
*Invited for Special Issue Celebrating Fred Wudl's 70th Birthday
2010
55) Grover, G. N.; Maynard, H. D. "Protein-Polymer Conjugates: Synthetic Approaches by Controlled Radical Polymerizations & Intersting Applications," Current Opin. Chem. Biol. 2010, 14, 818-827.
54) Chang, C. W.; Nguyen, T. H.; Maynard, H. D. "Thermoprecipitation of Glutathion S-Transferase by Glutathion-Poly(N-isopropylacrylamide) Prepared by RAFT Polymerization," Macromol. Rapid Commun. 2010, 31, 1691-1695.*
*Highlighted by Materials Views
*Chosen as "Best of Macromolecular Journals of 2011"
53) Heredia, K. L.; Tao, L.; Grover, G. N.; Maynard, H. D. "Heterotelechelic Polymers for Capture and Release of Protein-Polymer Conjugates," Polym. Chem. 2010, 1, 168-170.
52) Stuckel, J. M.; Li, R. C.; Maynard, H. D.; Caplan, M. R. "Two-step Synthesis of Multivalent Cancer-Targeting Constructs," Biomacromolecules, 2010, 11, 160-167.
51) Garrell, R. G.; Maynard, H. D., "Surface Molecular Property Control" in Biomedical Technology: Applications to Microfluidics, Nano Optics and Surface Chemistry, Edited by C. M. Ho, Oxford University Press: Oxford, 2010, Chapter 11, 395-435.
50) Christman, K. L.; Maynard, H. D., "Surface Patterning for Generating Defined Nanoscale Matrices" in Methods in Molecular Biology: Stem Cells for Myocardial Repair and Regeneration, Edited by R. Lee, Humana Press, Inc., Totowa, NJ, 2010, vol. 660, part 6, 225-263.
2009
49) Alconcel, S. N. S.; Grover, G. N.; Matsumoto, N. M.; Maynard, H. D. "Synthesis of Michael Acceptor Ionomers of Poly(4-Sulfonated Styrene-co-Poly(Ethylene Glycol) Methyl Ether Acrylate)," Aust. J. Chem. 2009, 62, 1496-1500.
48) Vazquez-Dorbatt, V.; Tolstyka, Z. P.; Maynard, H. D. "Synthesis of Aminooxy End-Functionalized pNIPAAm by RAFT Polymerization for Protein and Polysaccharide Conjugation," Macromolecules, 2009, 42, 7650-7656.
47) Grover, G. N.; Alconcel, S. N. S.; Matsumoto, N. M.; Maynard, H. D. "Trapping of Thiol-Terminated Acrylate Polymers with Divinyl Sulfone to Generate Well-Defined Semitelechelic Michael Acceptor Polymers," Macromolecules, 2009, 42 , 7657-7663.
46) Mancini, R. J.; Li, R. C.; Tolstyka, Z. P.; Maynard, H. D. "Synthesis of a Photo-caged Aminooxy Alkane Thiol," Org. Biomol. Chem. 2009, 7, 4954-4959.
45) Vazquez-Dorbatt, V.; Tolstyka, Z. P.; Chang, C. W.; Maynard, H. D. "Synthesis of a Pyridyl Disulfide End-Functionalized Glycopolymer for Conjugation to Biomolecules and Patterning on Gold Surfaces," Biomacromolecules, 2009, 10, 2207-2212.
44) Tao, L.; Kaddis, C. S.; Ogorzalek Loo, R. R.; Grover, G. N.; Loo, J. A.; Maynard, H. D. "Synthesis of Maleimide-End Functionalized Star Polymers and Multimeric Protein-Polymer Conjugates," Macromolecules, 2009, 42, 8028-8033.
43) Schopf, E.; Broyer, R. M.; Tao, L.; Chen, Y.; Maynard, H. D. "Directed Carbon Nanotube Assembly Using a Pyrene Functionalized Polymer," Chem. Commun. 2009, 4818-4820.
42) Bays, E.; Tao, L.; Chang, C. W.; Maynard, H. D. "Synthesis of Semi-Telechelic Maleimide Poly(PEGA) for Protein Conjugation by RAFT Polymerization," Biomacromolecules, 2009, 10, 1777-1781.
41) Chang, C. W.; Bays, E.; Tao, L.; Alconcel, S. A.; Maynard, H. D. "Differences in Cytotoxicity of Poly(PEGA)s Synthesized by Reversible Addition-Fragmentation Chain Transfer Polymerization," Chem.Commun. 2009, 3580-3582.
40) Tao, L; Kaddis, C. S.; Ogorzalek Loo, R. R.; Grover, G.N.; Loo, J. A.; Maynard, H. D. "Synthetic Approach to Homodimeric Protein-Polymer Conjugates," Chem. Commun., 2009, 2148-2150.
39) Heredia, K. L.; Grover, G. N.; Tao, L.; Maynard, H. D. "Synthesis of Heterotelechelic Polymers for Conjugation of Two Different Proteins," Macromolecules, 2009, 42, 2360-2367.*
*Chosen for cover of that issue, Highlighted on the American Chemical Society Main Webpage.
38) Christman, K. L.; Schopf, E.; Broyer, R. M.; Li, R. C.; Chen, Y.; Maynard, H. D. "Positioning Multiple Proteins at the Nanoscale with Electron Beam Cross-Linked Functional Polymers," J. Am. Chem. Soc. 2009, 131, 521-527.
37) Maynard, H. D.; Broyer, R. M.; Kolodziej, C. M. "Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry," in Click Chemistry for Biotechnology and Materials Science, Edited by J. Lahann, Wiley Inc., West Sussex, UK, 2009, Chapter 4, 53-68.
2008
36) Christman, Wong, T. S.; Brough, B.; Christman, K. L.; Kolodziej, C. M.; Huang, A.; Lam, R.; Forbes, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M. "Manufacture of Nanoscale Structures through Top-down and Bottom-up Approaches," Proceedings of the IEEE 7th International Conference on Nanotechnology, 2008, 126-130.
35) Christman, K. L.; Vazquez-Dorbatt, V.; Schopf, E.; Kolodziej, C. M.; Li, R. C.; Broyer, R. M.; Chen, Y.; Maynard, H. D. "Nanoscale Growth Factor Patterns by Immobilization on a Heparin Mimicking Polymer," J. Am. Chem. Soc. 2008, 130, 16585-16591.
34) Heredia, K. L.; Nguyen, T. H.; Chang, C. -W.; Bulmus, V.; Davis, T. P.; Maynard, H. D. "Reversible siRNA-Polymer Conjugates by RAFT Polymerization," Chem. Commun. 2008, 28, 3245-3247.
33) Tolstyka, Z. P.; Kopping, J. T.; Maynard, H. D. "Straightforward Synthesis of Cysteine-Reactive Telechelic Polystyrene," Macromolecules, 2008, 41, 599-606.
32) Broyer, R. M.; Quaker, G. M.; Maynard, H. D. "Designed Amino Acid ATRP Initiators for the Synthesis of Biohybrid Materials," J. Am. Chem. Soc., 2008, 130, 1041-1047.
2007
31) Mendes, P. M.; Christman, K. L.; Parthasarathy, P.; Schopf, E.; Ouyang, J.; Yang, Y.; Preece, J. A.; Maynard, H. D.; Chen, Y.; Stoddart, J. F. "Electrochemically Controllable Conjugation of Proteins on Surfaces," Bioconjugate Chem. 2007, 18, 1919-1923.
30) Kopping, J. T.; Tolstyka, Z. P.; Maynard, H. D. "Telechelic Aminooxy-Polystyrene Synthesized by ATRP and ATR Coupling," Macromolecules, 2007, 40, 8593-8599.
29) Hwang, J.; Li, R. C.; Maynard, H. D. "Well-Defined Polymers with Activated Ester and Protected Aldehyde Side Chains for Bio-functionalization," J. Controlled Release, 2007, 122, 279-286.
28) Maynard, H. D.; Heredia, K. L.; Li, R. C.; Parra, D. P.; Vazquez-Dorbatt, V. "Thermoresponsive Biohybrid Materials Synthesized by ATRP," J. Mater. Chem., 2007, 17, 4015-4017.*
*Invited for special theme issue on Biomaterials
27) Li, R. C.; Hwang, J.; Maynard, H.D. "Reactive Block Copolymer Scaffolds," Chem. Commun. 2007, 3631-3633.*
*Chosen for cover of that issue
26) Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D. "Aminooxy End-Functionalized Polymers Synthesized by ATRP for Chemoselective Conjugation to Proteins," Macromolecules, 2007, 40, 4772-4779.
25) Brough, B.; Christman, K. L.; Wong, T. S.; Kolodziej, C. M.; Forbest, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M. "Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns," Soft Matter, 2007, 3, 541-546.*
*Chosen for cover of that issue
24) Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Maynard, H. D. "Site-Specific Protein Immobilization through N-Terminal Oxime Linkages," J. Mater. Chem. 2007, 17, 2021-2027.*
*Invited for Emerging Investigators Special Issue
23) Heredia, K. L.; Maynard, H. D. "Synthesis of Protein-Polymer Conjugates," Organic & Biomol. Chem. 2007, 5, 45-53.*
*Chosen for cover of that issue, Among top cited papers of 2008
2002-2006
22) Christman, K. L.; Enriquez-Rios, V. D.; Maynard, H. D. "Nanopatterning Proteins and Peptides," Soft Matter, 2006, 2, 928-939.*
*Third most cited biological article in history of journal
21) Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D. "Submicron Streptavidin Patterns for Protein Assembly," Langmuir, 2006, 22, 7444-7450.
20) Li, R. C,; Broyer, R. M.; Maynard, H. D. "Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization," J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 5004-5013.
19) Vazquez-Dorbatt, V.; Maynard H. D. "Biotinylated Glycopolymers Synthesized by Atom Transfer Radical Polymerization," Biomacromolecules, 2006, 7, 2297-2302.
18) Heredia, K. L.; Bontempo, D.; Ly, T.; Byers, J. T.; Halstenberg, S.; Maynard, H. D. "In-Situ Preparation of Protein-’Smart’ Polymer Conjugates with Retention of Bioactivity, " J. Am. Chem. Soc. 2005, 127, 16955-16960.
17) Bontempo, D.; Li, R. C.; Ly, T.; Brubaker, C. E.; Maynard, H. D. "One-Step Synthesis of Low Polydispersity, Biotinylated Poly(N-Isopropylacrylamide) by ATRP," Chem. Commun. 2005, 37, 4702-4704.
16) Christman, K. L.; Maynard, H. D. "Protein Micropatterns Using a pH-Responsive Polymer and Light," Langmuir, 2005, 21, 8389-8393.
15) Maynard, H. D.; Hubbell, J. A. "Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor" Acta Biomaterialia, 2005, 1, 451-459.
14) Bontempo, D.; Maynard, H. D. "Streptavidin as a Macroinitiator for Polymerization: In Situ Protein-Polymer Conjugate Formation" J. Am. Chem. Soc. 2005, 127, 6508-6509.
13) Bontempo, D.; Heredia, K. L.; Fish, B. A.; Maynard, H. D. "Cysteine-Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Proteins," J. Am. Chem. Soc. 2004, 126, 15372-15373.
1989-2001
12) Maynard, H. D.; Lyu, S.; Fredrickson, G. H.; Wudl, F.; Chmelka, B. F. "Syntheses of Nanophase-Segregated Poly(vinyl acetate)-Poly(dimethylsiloxane) and Poly(vinyl acetate)-Poly(styrene) Graft Copolymers," Polymer, 2001, 42, 7567-7574.
11) Maynard, H. D.; Okada, S. Y.; Grubbs, R. H. "Inhibition of Cell Adhesion to Fibronectin by Oligopeptide-Substituted Polynorbornenes," J. Am. Chem. Soc. 2001, 123, 1275-1279.
10) Maynard, H. D.; Okada, S. Y.; Grubbs, R. H. "Synthesis of Norbornenyl Polymers With Bioactive Oligopeptides by Ring-Opening Metathesis Polymerization," Macromolecules, 2000, 33, 6239-6248.
9) Maynard, H. D.; Grubbs, R. H. "Synthesis of Functionalized Polyethers by Ring-Opening Metathesis Polymerization of Unsaturated Crown Ethers," Macromolecules, 1999, 32, 6917-6924.
8) Maynard, H. D.; Grubbs, R. H. "Purification Technique for the Removal of Ruthenium from Olefin Metathesis Reaction Products," Tetrahedron Lett. 1999, 40, 4137-4140.
7) Williams, S. R.; Maynard, H. D.; Chmelka, B. F. "Synthesis of 13C-Enriched Pyrrole from 2-13C D-Galactose," J. Labelled Cpd. Radiopharm. 1999, 42, 927-936.
6) Marsella, M. J.; Maynard, H. D.; Grubbs, R. H. "Template-Directed Ring-Closing Metathesis: Synthesis and Polymerization of Unsaturated Crown Ether Analogs," Angew. Chem. Int. Ed. Engl., 1997, 36, 1101-1103.
5) Wagener, K. B.; Patton, J. T.; Forbes, M. D. E.; Myers, T. L.; Maynard, H. D. "Acyclic Diene Metathesis Polymerization: The Synthesis of Unsaturated Polyketones," Polym. Intern. 1993, 32, 411-415.
4) Forbes, M. D. E.; Patton, J. T.; Myers, T. L.; Maynard, H. D.; Smith, D. W.; Schulz, G. R.; Wagener, K. B. "Solvent-Free Cyclization of Linear Dienes Using Olefin Metathesis and the Thorpe-Ingold Effect," J. Am. Chem. Soc. 1992, 114, 10978-10980.
3) Forbes, M. D. E.; Myers, T. L.; Dukes, K. E.; Maynard, H. D. "Biradicals and Spin-Correlated Radical Pairs Anchored to SiO2 Surfaces: Probing Diffusion at the Solid/Solution Interface," J. Am. Chem. Soc. 1992, 114, 353-354.
2) Forbes, M. D. E.; Dukes, K. E.; Myers, T. L.; Maynard, H. D.; Breivogel, C. S.; Jaspan, H. B. "Time-Resolved Electron Paramagnetic Resonance Spectroscopy of Organic Free Radicals Anchored to SiO2 Surfaces," J. Phys. Chem. 1991, 95, 10547-10549.
1) Maynard, M. S.; Maynard, H. D. "HPLC Assay for Avermectin B1a and its Two Photoisomers Using a Photo Diode Array Detector," Bull. Environ. Contam. Toxicol. 1989, 43, 499-504.
Featured In Press
1) Featured in article "Chairs of Distinction," UCLA Magazine, Summer 2003.
2) Featured in article "It's a Small, Small World," UCLA College Report, Spring-Summer 2004.
3) Featured in University of California Total Instructional Effort (TIE) a Visual Representation, June 2004.
4) Featured in article "Junior Faculty: Joining the Fight Against Cancer," UCLA Cancer Discoveries, 2004-2005.
5) Research featured as Hot Article on the Chemical Communications webpage in June 2008.
6) Interviewed by Nature's "Thescepticalchymist", July 2008.
7) Outreach activity "Parents' Weekend 2008" highlighted in UCLA College Report, Winter 2009, p. 3.
8) Interviewed by Highlights in Chemical Biology, May 2010.
9) Research featured on Materials Views, August 2010.
10) Outreach activity to Girl Scouts of Greater Los Angeles receives press, January 2011.
11) Author of the week for the Polymer Chemistry Blog, May 2011.
12 ) Included in Photo-Mosaic cover of Nature Chemistry, September 2011.